Serum urate and probability of dopaminergic deficit in early “Parkinson's disease”
Identifieur interne : 001389 ( Main/Exploration ); précédent : 001388; suivant : 001390Serum urate and probability of dopaminergic deficit in early “Parkinson's disease”
Auteurs : Michael A. Schwarzschild [États-Unis] ; Kenneth Marek [États-Unis] ; Shirley Eberly [États-Unis] ; David Oakes [États-Unis] ; Ira Shoulson [États-Unis] ; Danna Jennings [États-Unis] ; John Seibyl [États-Unis] ; Alberto Ascherio [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-08-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Aged, Diagnosis, Dopamine, Dopamine (metabolism), Dopamine Plasma Membrane Transport Proteins (deficiency), Female, Humans, Male, Middle Aged, Nervous system diseases, Odds Ratio, Parkinson Disease (blood), Parkinson Disease (metabolism), Parkinson Disease (radionuclide imaging), Parkinson disease, Parkinson's disease, Probability, Retrospective Studies, Sex Factors, Tomography, Emission-Computed, Single-Photon, Tropanes (diagnostic use), Uric Acid (blood), biomarker, diagnosis, dopamine transporter, neuroimaging, urate.
- MESH :
- chemical , blood : Uric Acid.
- chemical , deficiency : Dopamine Plasma Membrane Transport Proteins.
- chemical , diagnostic use : Tropanes.
- chemical , metabolism : Dopamine.
- blood : Parkinson Disease.
- metabolism : Parkinson Disease.
- radionuclide imaging : Parkinson Disease.
- Adult, Aged, Female, Humans, Male, Middle Aged, Odds Ratio, Probability, Retrospective Studies, Sex Factors, Tomography, Emission-Computed, Single-Photon.
Abstract
The objective of this study was to investigate whether higher levels of urate, an antioxidant linked to a lower likelihood of developing Parkinson's disease, is also a predictor of having a dopamine transporter brain scan without evidence of dopaminergic deficit. In a cross‐sectional study of 797 mildly affected, untreated parkinsonian subjects diagnosed with early Parkinson's disease in the Parkinson Research Examination of CEP‐1347 Trial, we investigated the relationship at baseline between serum urate and striatal dopamine transporter density, determined by single‐photon emission computed tomography of iodine‐123‐labeled 2‐β‐carboxymethoxy‐3‐β‐(4‐iodophenyl)tropane uptake. A scan without evidence of dopaminergic deficit was defined as lowest putamen iodine‐123‐labeled 2‐β‐carboxymethoxy‐3‐β‐(4‐iodophenyl)tropane > 80% age‐expected putamen dopamine transporter density. The odds of having a scan without evidence of dopaminergic deficit rose across increasing quintiles of urate level, with an age‐ and sex‐adjusted odds ratio of 3.2 comparing the highest to the lowest urate quintile (95% confidence interval, 1.5–7.2; P for trend = .0003), and remained significant after adjusting for potential confounding factors. The association was significant in men but not women, regardless of whether common or sex‐specific quintiles of urate were used. Higher levels of urate were associated with a greater likelihood of a scan without evidence of dopaminergic deficit among subjects with early untreated parkinsonism in the Parkinson Research Examination of CEP‐1347 Trial. The findings support the diagnostic utility of urate in combination with other determinants. © 2011 Movement Disorder Society
Url:
- https://api.istex.fr/document/9217CF0BE19CFAC02CAEDB77C00779BAEE40BFC6/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150627
DOI: 10.1002/mds.23741
Affiliations:
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Le document en format XML
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<term>Dopamine</term>
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<term>Dopamine Plasma Membrane Transport Proteins (deficiency)</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Nervous system diseases</term>
<term>Odds Ratio</term>
<term>Parkinson Disease (blood)</term>
<term>Parkinson Disease (metabolism)</term>
<term>Parkinson Disease (radionuclide imaging)</term>
<term>Parkinson disease</term>
<term>Parkinson's disease</term>
<term>Probability</term>
<term>Retrospective Studies</term>
<term>Sex Factors</term>
<term>Tomography, Emission-Computed, Single-Photon</term>
<term>Tropanes (diagnostic use)</term>
<term>Uric Acid (blood)</term>
<term>biomarker</term>
<term>diagnosis</term>
<term>dopamine transporter</term>
<term>neuroimaging</term>
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<term>Male</term>
<term>Middle Aged</term>
<term>Odds Ratio</term>
<term>Probability</term>
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<front><div type="abstract" xml:lang="en">The objective of this study was to investigate whether higher levels of urate, an antioxidant linked to a lower likelihood of developing Parkinson's disease, is also a predictor of having a dopamine transporter brain scan without evidence of dopaminergic deficit. In a cross‐sectional study of 797 mildly affected, untreated parkinsonian subjects diagnosed with early Parkinson's disease in the Parkinson Research Examination of CEP‐1347 Trial, we investigated the relationship at baseline between serum urate and striatal dopamine transporter density, determined by single‐photon emission computed tomography of iodine‐123‐labeled 2‐β‐carboxymethoxy‐3‐β‐(4‐iodophenyl)tropane uptake. A scan without evidence of dopaminergic deficit was defined as lowest putamen iodine‐123‐labeled 2‐β‐carboxymethoxy‐3‐β‐(4‐iodophenyl)tropane > 80% age‐expected putamen dopamine transporter density. The odds of having a scan without evidence of dopaminergic deficit rose across increasing quintiles of urate level, with an age‐ and sex‐adjusted odds ratio of 3.2 comparing the highest to the lowest urate quintile (95% confidence interval, 1.5–7.2; P for trend = .0003), and remained significant after adjusting for potential confounding factors. The association was significant in men but not women, regardless of whether common or sex‐specific quintiles of urate were used. Higher levels of urate were associated with a greater likelihood of a scan without evidence of dopaminergic deficit among subjects with early untreated parkinsonism in the Parkinson Research Examination of CEP‐1347 Trial. The findings support the diagnostic utility of urate in combination with other determinants. © 2011 Movement Disorder Society</div>
</front>
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<li>Massachusetts</li>
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<tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Schwarzschild, Michael A" sort="Schwarzschild, Michael A" uniqKey="Schwarzschild M" first="Michael A." last="Schwarzschild">Michael A. Schwarzschild</name>
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<name sortKey="Ascherio, Alberto" sort="Ascherio, Alberto" uniqKey="Ascherio A" first="Alberto" last="Ascherio">Alberto Ascherio</name>
<name sortKey="Ascherio, Alberto" sort="Ascherio, Alberto" uniqKey="Ascherio A" first="Alberto" last="Ascherio">Alberto Ascherio</name>
<name sortKey="Eberly, Shirley" sort="Eberly, Shirley" uniqKey="Eberly S" first="Shirley" last="Eberly">Shirley Eberly</name>
<name sortKey="Jennings, Danna" sort="Jennings, Danna" uniqKey="Jennings D" first="Danna" last="Jennings">Danna Jennings</name>
<name sortKey="Marek, Kenneth" sort="Marek, Kenneth" uniqKey="Marek K" first="Kenneth" last="Marek">Kenneth Marek</name>
<name sortKey="Oakes, David" sort="Oakes, David" uniqKey="Oakes D" first="David" last="Oakes">David Oakes</name>
<name sortKey="Seibyl, John" sort="Seibyl, John" uniqKey="Seibyl J" first="John" last="Seibyl">John Seibyl</name>
<name sortKey="Shoulson, Ira" sort="Shoulson, Ira" uniqKey="Shoulson I" first="Ira" last="Shoulson">Ira Shoulson</name>
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